tom-1, a novel v-Myb target gene expressed in AMV- and E26-transformed myelomonocytic cells
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چکیده
منابع مشابه
Neoplastic transformation by E26 leukemia virus is mediated by a single protein containing domains of gag and myb genes.
The genome of avian leukemia virus E26 shares homology with v-myb, the oncogene of avian myeloblastosis virus, and encodes a protein with an Mr of 135,000. Analyses of tryptic oligopeptides show that this protein is related to the proteins encoded by gag (Pr76gag) as well as v-myb (p45v-myb[AMV] ) and c-myb (p75c-myb). We found no evidence for the existence of additional myb-related proteins or...
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PURPOSE We investigated the expression of human endogenous retrovirus K (HERV-K) transcripts in various tumor tissues and transformed cell lines. EXPERIMENTAL DESIGN We performed reverse transcription-PCR analysis to examine expression of env reading frame transcripts in mammary carcinoma biopsies, germ-cell tumor samples, ovarian carcinomas, and lymphocytes of leukemic patients, as well as i...
متن کاملCells transformed by a v-Myb-estrogen receptor fusion differentiate into multinucleated giant cells.
In order to make conditional alleles of the v-myb oncogene, we constructed and tested avian retroviruses which produce a number of different fusion proteins between v-Myb and the human estrogen receptor (ER). We found that the portion of the ER used in making these fusions profoundly affected their transcriptional activation. However, all the fusions tested were only weakly transforming in embr...
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The homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV). GBX2 activation by c-Myb requires signal transduction emanating from the cell surface while the leukemogenic AMV v-Myb constitutively induces the GBX2 gene. Mutations in the DNA binding domain of AMV-Myb render it independent of signaling events and concomitantly abro...
متن کاملv-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter.
The oncogenic transcription factor v-Myb disrupts myelomonocytic differentiation and transforms myelomonocytic cells by deregulating the expression of specific target genes. One of these genes, the chicken mim-1 gene, is activated by Myb exclusively in myelomonocytic cells and, therefore, has been an interesting model system to study how Myb activates a target in a lineage-specific manner. Prev...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1997
ISSN: 1460-2075
DOI: 10.1093/emboj/16.6.1371